Alzheimer's Disease Image of Brain

What is Alzheimer’s?

Alzheimer’s is a progressive neurologic disorder that begins with memory loss and thinking skills- but can progressively affect an individual’s ability to carry out their daily activities. It may even lead to changes in an individual’s behavior or personality. This progressive memory loss results from the disorder causing the brain to shrink and brain cells to die.

How Does Alzheimer’s Change the Brain?

The brain contains many neurons that process and transmit information through electrical and chemical signals. These pathways allows continuous communication between different parts of the brain and body. However, Alzheimer’s is a disorder that disrupts this communication and leads to loss of function and cell death. While it is normal for the brain to shrink with age, Alzheimer’s causes widespread damage and loss of neurons. This disruption begins with damage to neurons involved in memory. However, it will later affect areas of the brain associated with language, reasoning, and social behavior. This damage will then spread to other areas- which can seriously impact an individual’s ability to live and function independently.

How Is Alzheimer’s Disease Diagnosed?

Your doctor can diagnose you with Alzheimer’s by administering tests that assess your memory and thinking skills. Your doctor may start with a physical and neurological exam to assess your reflexes, muscle tone, strength, ability to get up and walk around, sense of sight and hearing, coordination, and balance. Meanwhile, blood tests can help doctors rule out the possibility that your memory loss results from other disorders or vitamin deficiencies. If they suspect that you may have Alzheimer’s, they may also refer you to a specialist (such as a neurologist). There, the specialist will be able to carry out more extensive tests. Mental and neuropsychological testing will allow doctors to discover additional details about your mental function (as well as point out possible symptoms that may arise in the future). Brain imaging can also allow doctors to discover possible brain abnormalities that may indicate other conditions (such as tumors or strokes).

What Causes Alzheimer’s?

The exact cause of Alzheimer’s is not yet fully understood. Many believe it is caused by an abnormal build-up of two proteins in and around brain cells. One of those proteins is Beta-amyloid fragments, which clusters and form plaques around brain cells. They harm neurons and cell communication. Meanwhile, Tau proteins change shape and form tangles within brain cells. These tangles lead to a disruption in transport systems and are harmful to cells.

Studies and researchers also point out that Alzheimer’s may result from a combination of:

  • Age-related changes- As people age, changes such as shrinking, inflammation, blood vessel damage, and breakdown of energy within cells occur within the brain. These changes can harm the neurons and other cells within the brain- increasing the chances of Alzheimer’
  • Family history- Changes or differences in genes may be passed down by a family member. However, this is rare because less than 1% of the time, Alzheimer’s (with an early onset occurring during someone’s 30s-40s) is caused by changes in the gene.
  • Head injuries- Many studies show a link where head injury can increase one’s chances of dementia/Alzheimer’
  • Health, environmental, and lifestyle factors- Factors such as exposure to pollutants, socioeconomic status, diet, exercise, the propensity to infections, smoking, heart disease, stroke, high blood pressure, diabetes, and obesity can play a role in Alzheimer’

What Does Alzheimer’s Do to a Person?

Keep in mind that every individual will be affected differently by this disorder. Some may experience a more rapid progression of symptoms. Meanwhile, for others, progression of symptoms may take time. To better understand how Alzheimers can affect a person, it is best to break it down to the following three stages:

  1. Mild Alzheimer’s disease: People may start to wander, get lost, have trouble handling money or paying bills, repeat questions, take longer to complete their everyday tasks, or have noticeable changes in their personality and behavior.
  2. Moderate Alzheimer’s disease: Damage occurs to the area of the brain that controls language, reasoning, conscious though, and sensory processing occurs within this stage. One may also notice an individual’s memory loss and confusion worsen as they tend to have issues recognizing/remembering family and friends. At this stage, they may even have trouble remembering new things, coping with new situations, or carrying out multistep tasks. Others may begin experiencing hallucinations, delusions, and paranoia- resulting in impulsive behavior.
  3. Severe Alzheimer’s disease: At this stage, the plaques and tangles within the brain worsen, and the brain shrinks significantly. Individuals may not be able to communicate and have to rely on others for their care. Towards the end, people tend to stay in bed or chair most of the time.

What Are the 7 Stages of Alzheimer’s?

We have already broken down the three stages of Alzheimer’s. However, other organizations often break down this disease into seven stages. These 7 stages include:

Stage 1. No impairment

  • Changes within the brain begin to occur, but they are not noticeable through symptoms yet. Only a PET scan (imaging test of the brain) can indicate if you have Alzheimer’

Stage 2. Very mild cognitive decline

  • Small changes may begin to show as individuals forget more often. This changes can include actions such as forgetting words, forgetting names, or misplacing objects. However, one can still drive, work, and engage in social activities without issue.

Alzheimer's Disease | Patient Elderly Person Suffering from Memory Loss

Stage 3. Mild cognitive decline

  • Friends, family, and other colleagues may begin to notice memory difficulties. These issues may include:
  • Having trouble remembering what they just read
  • Asking the same question over and over again
  • Having difficulty making plans or organizing
  • Not remembering names when meeting new people
  • Losing or misplacing valuable objects
  • Increasing difficulty in planning or organizing
  • Having more difficulty performing tasks in social or work settings
  • Having trouble coming up with the right words or names

Stage 4. Moderate cognitive decline

  • People tend to stay within this stage for a few years. Any issues in memory and reason will become more noticeable, and individuals may need some help with their everyday activities. Individuals may:
  • Forget details about themselves
  • Forget what month or season it is
  • Have trouble cooking or ordering meals
  • Struggle using the phone
  • Have confusion with what is being said to them
  • Struggle to do multi-step tasks
  • Have confusion about where they are
  • Have a higher risk of wandering off or getting lost
  • Have changes in sleep patterns
  • Become moody or withdrawn

Stage 5. Moderately severe cognitive decline

  • Lapses in memory and judgment will decline more within this stage. Most individuals will need more help with their daily activities. For example, people may:
  • Be unable to remember their address, phone number, or where they graduated from high school, or college
  • Become confused about what day it is
  • Struggle more with getting dressed
  • Experience hallucinations, delusions, and paranoia

Stage 6. Severe cognitive decline

  • Symptoms will worsen and may heavily impact your loved one’s ability to live independently. Individuals may:
  • Forget recent experiences
  • Lose awareness of their current surroundings
  • Remember their name, but have trouble recalling their personal history
  • Be able to distinguish faces, but have issues remembering names
  • Need help in dressing properly
  • Have extreme changes/disruptions in sleep patterns
  • Lose control of bladder or bowels
  • Show changes in personality and behavior
  • Difficulties in communicating specific thoughts

Stage 7. Very severe cognitive decline

  • At this stage, the destruction/damage of bran cells leads to severe mental and physical impairment. People will begin to lose their ability to respond to their environment, carry out a conversation, or control their movements. At this stage, individuals will need help with daily personal care (such as bathing, eating, using the toilet, brushing their teeth, etc.). They may also need around-the-clock care to help with walking, sitting, holding their head up, and swallowing. Due to issues in swallowing and decreased mobility, individuals become more vulnerable to infections such as pneumonia.

What Is the Difference Between Alzheimer’s and Dementia? 

Dementia is an umbrella term that describes a wide range of symptoms that affect a person’s ability to independently perform everyday activities. It often refers to a group of diseases (Alzheimer’s being one). Meanwhile, Alzheimer’s is a brain-specific disease (often marked by symptoms of dementia) caused by complex brain changes that lead to cell damage.

Are Alzheimer’s and Dementia the Same?

As discussed above, Dementia is the umbrella term that describes a wide range of symptoms that leads to a decline in memory and thinking skills. Dementia itself is not a disease. Instead, it is a symptom of an underlying brain disorder. Meanwhile, Alzheimer’s is a brain-specific disorder. 

What Are the 5 Types of Dementia?

1) Alzheimer’s disease:
Alzheimer’s is the most common type of dementia. Patients tend to have plaques and tangles of Beta-amyloid or Tau proteins within their brain. These proteins can damage neurons and disrupt cell communication pathways.

2) Vascular dementia:
Vascular dementia often results from damage of blood vessels that supply blood to your brain (resulting in a deprivation of oxygen and nutrients). For example, strokes can cause major blocks in blood vessels within the brain. This blockage can lead to changes in thinking skills. If it continuously occurs, this can lead to more widespread damage. Some common signs include difficulties in problem-solving, slow thinking, loss of focus, and loss of organization.

3) Lewy body dementia:
Lewy bodies are balloon-like clumps of protein found in the brain. People with Alzheimer’s or Parkinson’s disease tend to get these clumps around the brain. Some common symptoms may include visual hallucinations, problems with focus and attention, uncoordinated/slow movement, tremors, rigidity, and acting out one’s dreams in sleep. Overall, Lewy body dementia leads to a progressive decline in thinking, reasoning, and independent function due to the microscopic deposits damaging the brain cells over time. It is the third most common cause of dementia after Alzheimer’s and vascular dementia.

4) Frontotemporal dementia:
This kind of dementia refers to a group of diseases where there is a breakdown of nerve cells and their connection to the frontal and temporal lobes of the brain. As a result, this impacts one’s personality, behavior, and ability to produce or comprehend language. One may also experience symptoms affecting behavior, personality, thinking, judgment, language, and movement.

5) Mixed dementia:
Autopsies in specific individuals show that people (80 or older) may have had a combination of different types of dementia. The most common combination is often Alzheimer’s and vascular dementia. Other cases include Alzheimer’s mixed with Lewy bodies. Symptoms will vary between individuals and on which brain regions are affected.

What Are the 10 Warning Signs of Alzheimer’s Disease? 

  1. Memory loss that disrupts daily life
  2. Challenges in planning or solving problems
  3. Difficulty performing familiar tasks
  4. Confusion with time and/or place
  5. Trouble understanding visual images and spatial relations
  6. Having new problems with words in speaking or writing
  7. Misplacing things and losing the ability to retrace steps
  8. Decreased or poor judgment
  9. Withdrawal from work or social activities
  10. Changes in mood, personality, or behavior

Where Does Alzheimer’s Start? 

Alzheimer’s begins in the brain and destroys neurons connected to areas of the brain involved with memory. As time passes, the disease eventually affects other parts of the cerebral cortex responsible for language, reasoning, and social behavior.

Alzheimer's Disease Affecting Older People | Image of Older Lady

Who Is Most Likely to Get Alzheimer’s?

While there is no known direct cause of Alzheimer’s, several factors may increase your risk of developing this disease later in life. These risk factors include:

  • Age: Alzheimer’s tends to develop within people over age 65. Many studies show that this risk doubles as five years pass by. However, it is possible for some people to develop this disease earlier.
  • Gender: Women are twice as likely to develop Alzheimer’s than men. The reason is still unknown, but many theorize that it may connect with the occurence that women tend to live longer than men. Others theorize it has to do with losing the hormone oestrogen after menopause.
  • Genetic Inheritance: While rare, there are few cases where it is clear that Alzheimer’s genes are being passed from generation to generation within families. Having a family member with Alzheimer’s (such as a parent or sibling) increases your risk. However, that is not to say that you will definitely develop this disease. Or that someone without a family history of Alzheimer’s has no chance of having it later in life.
  • Lifestyle: People who live a healthy lifestyle tend to have a decreased risk of getting Alzheimer’ Living a healthy lifestyle means doing regular/enjoyable exercise, maintaining a healthy weight, not smoking, eating a healthy and balanced diet, and limiting alcohol consumption. As one ages in life, it is also critical to keep mentally and socially active.
  • Health Problems: People with diabetes, stroke, high blood pressure, high cholesterol, obesity, or heart problems are at a higher risk of developing Alzheimer’

Can Alzheimer’s Be Cured?

As of now, there is no cure for Alzheimer’s. However, there are various treatments that can help slow the progression and reduce symptoms of the disease as you age. These treatments include:

1) Medicines:

  • Acetylcholinesterase (AChE) inhibitors: Your doctor can prescribe AChE medications to help increase levels of acetylcholine. These medications should improve how nerve cells communicate with one another.
  • Memantine: This medication is prescribed to patient with moderate/severe Alzheimer’s disease. It blocks the effects of an excessive amount of glutamate (a chemical found in the brain).
  • Medicines to treat challenging behavior: There are certain medications (such as antidepressants, risperidone, antipsychotic medicines, etc.) a healthcare provider may prescribe to patients. These prescriptions tend to occur in the later stages of dementia when individuals show more signs of behavioral and psychological symptoms.

2) Therapies and Activities:

  • Cognitive stimulation therapy: This kind of therapy involves an individual participating in group activities intended to improve memory and problem solving skills.
  • Cognitive rehabilitation: This kind of therapy gets you to work the parts of your brain that work to help out the other parts that are unable achieve a specific goal. This therapy is done with the help of a professional and a friend/relative.
  • Reminiscence and life story work: This kind of activity gets individuals to talk about their past and can involve items that trigger these memories.

Can Alzheimer’s Be Inherited?

Yes, as mentioned above, it is possible for there to be a clear genetic component of developing Alzheimer’s within family generations. However, this kind of Alzheimer’s is rare and typically develops in adults between the age of 30-40.

Can Alzheimer’s Be Prevented?

Because the direct cause of Alzheimer’s is still not known, there is no definitive way to prevent Alzheimer’s from occurring. However, there are actions you can take to help reduce your risks. These steps include:

  • Reducing your risk of cardiovascular disease
  • quit smoking
  • Limit alcohol consumption
  • Eating a healthy, balanced diet
  • Incorporating regular exercise into your daily routine (it is recommended to at least get 150 minutes of moderate-intensity aerobic activity)
  • Keeping your blood pressure under control
  • Ensuring you are following your diet and medication plan if you have diabetes
  • Staying mentally and socially active
  • Read
  • Learn a new language
  • Volunteer with your local community
  • Join a sport
  • Try new activities/hobbies
  • Maintain an active and social life
  • Do brain puzzles/games
  • Get enough sleep

Can Alzheimer’s Be Reversed?

While more studies have emerged to better understand the effects Alzheimer’s has on the brain, there is no way to reverse the disease. However, medications and treatments can slow the progression of the disease.

Can Alzheimer’s Come On Suddenly?

Disease progression will vary between individuals. For some, the development of the disease may be slow. For others, it may be fast. Usually, cognitive decline progresses slowly in most individuals. However, some may experience what is known as rapidly progressive dementias. While rare and tricky to diagnose, this dementia progresses quickly within the span of a couple of weeks or months (sometimes even up to 2-3 years).

Can Alzheimer’s Disease Kill You?

Alzheimer’s is usually not listed as the direct cause that leads to death. Instead, it often leads to complications in brain function that lead to death. In the last stage of Alzheimer’s, individuals may:

  • Have difficulty communicating or using language coherently
  • Be unable to recognize loved ones
  • Need help with personal care, eating, getting dressed, and using the bathroom
  • Have difficulty swallowing
  • Lose bladder and bowel control
  • Experiences hallucinations and delusions
  • Show more aggressive behavior due to fear or confusion
  • Spend more time in bed or on a chair

Because individuals tend to experience more difficulty  swallowing, this can lead to a higher chance of dying from pneumonia. Food and beverages have a higher chance of entering the lungs and causing infection. Other causes of death may include dehydration, malnutrition, and other infections. Overall, this disease significantly affects the brain and leads to the body shutting down.

Can I Have Alzheimer’s at 40??

People in their 30s or 40s can get Alzheimer’s. When people get Alzheimer’s under the age of 65, it is known as early-onset Alzheimer’s disease. Generally, this type of disease stems from the same factors that contribute to the development of Alzheimer’s in older individuals. However, in rare cases, there is familial Alzheimer’s disease. Less than a hundred people have genes that directly contribute to their development of Alzheimer’s. As a result, they start showing symptoms of the disease within their 30s, 40s, or 50s. Triggers for the disease have yet to be further studied. However, researchers believe it has to do with the two damaging proteins known as beta-amyloid and tau.

Do Alzheimer’s Patients Sleep a Lot?

Yes, it is common for individuals with Alzheimer’s (especially those in a later stage) to sleep a lot during the day and night. Disease progression can lead to more extensive damage to the brain, which leads to an individual becoming weaker/tired over time. Drowsiness may also be a side effect of certain medications the individual may be taking to help treat the disease.

Does Dementia Run in Families?

It is important to note that most dementias are not passed down between family members. It is possible, but this kind of dementia is rare and only accounts for a small percentage of dementia cases. For example, young-onset Alzheimer’s disease is when a faulty gene is passed down from parent to child. It usually results in individuals developing Alzheimer’s at the age 30-40. Other rare types of dementia may result from Huntington’s disease or Familial Prion disease (generally caused by a singly faulty ‘dominant’ gene).

How Long Does Alzheimer’s Take to Develop?

The answer to this question will vary between each individual. According to research, people tend to live another 4-8 years after their diagnosis. However (with the development of treatments), people can live up to 20 years after diagnosis. We highly encourage you to meet with your doctor if you suspect that you or your loved one is showing early signs and symptoms to ensure you receive a diagnosis and begin treatment as soon as possible.

How Many Alzheimer’s Patients in the US?

According to alz.org, they estimate that about 6.5 million Americans (age 65 and older) currently have Alzheimer’s dementia in the year 2022. About 72% of those are aged 75 years or older. Unfortunately, It also appears that these numbers will rise as time move forward. For example, the website also estimates that each state will experience an average 6.7% increase in people with Alzheimer’s between 2020-2025.

How Much Does Alzheimer’s Care Cost?

According to alz.org, they estimate that the total cost for individuals with Alzheimer’s or other dementias (in 2022) is about $321 billion. Of that number, Medicare and Medicaid cover about $206 billion (64%) of the total health care and long-term care payments. Meanwhile, out-of-pocket expenses are estimated to be about $81 billion (25%) of total payments. Of course, these expected costs will vary between each state and the level of care needed.

What Are the Do’s and Don’ts When Communicating with Someone with Alzheimer’s? 

It is important to keep in mind that (at the end of the day) it can be scary and difficult for someone to be diagnosed with Alzheimer’s. We encourage family members and loved ones to be patient and understanding since communication can become difficult for their loved ones as time passes. We encourage you not to:

  • Reason
  • Argue
  • Insist
  • Confront
  • Remind them of their forgetfulness
  • Remind them that someone has passed away
  • Bring up topics that will/may upset them
  • Question their recent memory
  • Take things personally

Instead, you should:

  • Give short, one-sentence explanations.
  • Allow plenty of time for comprehension
  • Repeat instructions or sentences exactly the same way (better if you check at least three times with them).
  • Agree with them or distract them with a different subject or activity.
  • Accept the blame when something’s wrong.
  • Step away, if necessary, to avoid confrontations.
  • Be patient, cheerful, and reassuring.
  • Practice 100% forgiveness.

Sources: www.cdc.gov, www.mayoclinic.org, www.alzheimers.gov, www.alz.org

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